Registration Number
0222U005257,
0122U002191
, R & D reports
Title
Search and synthesis of antiviral agents among nitrogencontaining heterocycle derivatives
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Head
Kachaeva Maryna V.,
Registration Date
27-12-2022
Organization
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
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New QSAR models with high stability and predictive ability for cytomegalovirus, varicella zoster virus and papillomavirus were created on the basis of the formed database of chemical compounds of azole derivatives with antiviral properties using the OCHEM online platform. 16 compounds have been identified and proposed for research. The following compounds were the most promising for further study: 5-(4-(3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-2-(p-tolyl)oxazol-4-carbonitrile against human cytomegalovirus (strain AD169), as well as 5-(2-(hydroxymethyl)pyrrolidin-1-yl)-2-phenyl-1,3-oxazole-4-carbonitrile and 5-(bis(2-hydroxyethyl)amino)-2-phenyl-1,3-oxazole-4-carbonitrile against varicella zoster virus (Ellen strain). The obtained results are fundamental and can be used to design new antiviral agents against different virus strains.
Product Description
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Hodyna Diana M.
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2022-12-27
