Registration Number
0223U000271,
0122U000443
, R & D reports
Title
Development of new approaches to the synthesis of fluorine-containing polyfunctionalized natural compounds and their structural analogues
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Head
Herus Ihor I., д.х.н.
Registration Date
05-01-2023
Organization
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
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The aim of the work is the design and development of methods for the synthesis of new polyfluoroalkyl-containing building blocks, on the basis of which the methods of synthesis of new bioactive compounds such as fluorine-containing alkaloids of the pyrrolidine series will be developed.
The practical significance of the obtained results lies in the development of a practical method for obtaining polyfluoroalkylpyrroles, effective approaches to the synthesis of fluorinated analogs of pyrrolidine alkaloids, potentially biologically active compounds of a heterocyclic nature using new low molecular weight functionalized building blocks.
We summarized and systematized literature data on the synthesis of fluorinated analogs of pyrrolizidine, indolizidine and quinolizidine alkaloids, etc. A new general and simple method of obtaining polyfluoroalkylpyrroles, which are promising starting compounds for the synthesis of fluorinated alkaloid derivatives of the pyrrolizidine series, has been developed. The cyclization formation of polyfluoroalkylpyrroles from N-(β-trifluoroacetyl)vinyl (TFAV) derivatives of proline and other α-amino acids was studied.
Product Description
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Bugera Maksym Ya.
Vdovenko Sergiy I.
Dolovanyuk Violetta G.
Klipkov Аnton А.
Kondratov Ivan S.
Kulik Irіna B.
Logvinenko Ivan G.
Romanenko Vladyslav D.
Ruchko Evgenia V.
Sorochynskyi Oleksandr Ye.
Tarasenko Karen V.
Fedorenko Оlena А.
Feskov Іlia О.
Hilchevskiy Oleksandr М.
Shaitanova Olena M.
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2023-01-06
