Registration Number
0223U000277,
0121U107435
, R & D reports
Title
Synthesis and study of fused heterocyclic systems containing the 7-deazapurine fragment
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Head
Smolii Oleh B., д.х.н.
Registration Date
05-01-2023
Organization
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
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Approaches to the synthesis of new functionalized 7-deazapurine derivatives were developed and halogenation reactions of 7-alkynyl-substituted pyrrolo[2,3-d]pyrimidines were studied. Based on the methyl ester of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid have been found effective methods of obtaining 9-functionally substituted of 7-deazapurine derivatives. A simple and fast method for obtaining new 3(4),7-disubstituted pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidine derivatives – structural analogues of trilaciclib, an effective drug in the treatment of small cell lung cancer – is proposed.
Product Description
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Biletsky Igor І.
Vaskevych Alla I
Verves Evgeniy V.
Gayevsky Anatoly P.
Zinchenko Hanna M.
Kucher Oleksandr V.
Muzychka Lyubov V.
Yaremchuk Iryna О.
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2023-01-06
