Registration Number
0223U000900,
0121U107434
, R & D reports
Title
Study of the features of the influence of binary radiation technologies on human malignant cells in vitro
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Head
Lavrenchuk Halyna Yo., д.б.н.
Talko Victoriia V., Доктор медичних наук
Registration Date
21-01-2023
Organization
State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine"
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Object of research: biological effects in cultures of normal and malignant human cells under the combined influence of binary radiation technologies. Objective: to investigate the structural and morpho-functional changes in the test systems of malignant (line A-549) and normal (fibroblasts) human cells when combining X-ray radiation with the gadolinium-containing photon-capturing agent "Dotavist" and red light with the photosensitizer "Fotolon". Research methods: method of transplanted culture of cells of normal human fibroblasts and malignant human cells, methods of irradiation with X-rays, red light, cytological, statistical. The influence of two binary radiation technologies separately and in combination was investigated in a comparative aspect, and the peculiarities of the effect on malignant and normal cells were determined based on morphofunctional characteristics (growth kinetics, proliferative and mitotic activity). The obtained results essentially form the basis of the preclinical stage of evaluating the effectiveness of drugs used in binary technologies, in particular "Dotavist" in the case of the photon capture method and "Photolon" for photodynamic therapy.
Product Description
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Atamanyk Natalia Pavlivna
Dmytrieva Inna Rudolfivna
Malyshevska Evgenia Myhalivna
Pochapinckui Oleksiu Dmytrovych
Chernyshov Andriu Viktorovych
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2023-01-21
