Search academic texts

Registration Number

0223U001007, 0120U103044 , R & D reports

Title

To study the impact factors and predictors of hepatic fibrosis formation in children with non-alcoholic fatty liver disease and to justify new approaches to diagnostic and therapeutic management

popup.stage_title

Head

Stepanov Yurii M., Доктор медичних наук

Registration Date

24-01-2023

Organization

State institution Institute of gastroenterology of nams of Ukraine

popup.description2

The study of clinical and anamnestic and laboratory-instrumental differences in the stages of development of fibrosis in NAFLD in children with obesity was carried out. Body composition was studied by means of bioimpedance analysis in children with NAFLD, taking into account the presence of liver fibrosis. The peculiarities of the lipid spectrum, carbohydrate metabolism, serum markers of fibrosis in children with NAFLD, depending on the presence of liver fibrosis, were studied. Features of intestinal microflora (spectrum of faecal CFA, presence of SNBR) and lactose assimilation in children with NAFLD, depending on the presence of liver fibrosis, were characterized. Changes in the apoptosis marker cytokeratin-18, cytokine profile, growth factors (VEGF, TGF-β1) depending on the presence of liver fibrosis were analyzed. The diagnostic value of non-invasive immunological and biochemical markers in the diagnosis of liver fibrosis with NAFLD in children was determined. An algorithm for non-invasive diagnosis of liver fibrosis in children with NAFLD has been developed. 

Product Description

popup.authors

Zavgorodnyaya Natalya Yu
Zigalo Elvira V.
Kislova Raisa Mikolaivna
Klenina Ina Anatoliivna
Petishko Oksana P
Tatarchuk Oksana M.

popup.nrat_date

2023-01-24