Search academic texts

Information × Registration Number 0223U001007, 0120U103044 , R & D reports Title To study the impact factors and predictors of hepatic fibrosis formation in children with non-alcoholic fatty liver disease and to justify new approaches to diagnostic and therapeutic management popup.stage_title Head Stepanov Yurii M., Доктор медичних наук Registration Date 24-01-2023 Organization State institution Institute of gastroenterology of nams of Ukraine popup.description2 The study of clinical and anamnestic and laboratory-instrumental differences in the stages of development of fibrosis in NAFLD in children with obesity was carried out. Body composition was studied by means of bioimpedance analysis in children with NAFLD, taking into account the presence of liver fibrosis. The peculiarities of the lipid spectrum, carbohydrate metabolism, serum markers of fibrosis in children with NAFLD, depending on the presence of liver fibrosis, were studied. Features of intestinal microflora (spectrum of faecal CFA, presence of SNBR) and lactose assimilation in children with NAFLD, depending on the presence of liver fibrosis, were characterized. Changes in the apoptosis marker cytokeratin-18, cytokine profile, growth factors (VEGF, TGF-β1) depending on the presence of liver fibrosis were analyzed. The diagnostic value of non-invasive immunological and biochemical markers in the diagnosis of liver fibrosis with NAFLD in children was determined. An algorithm for non-invasive diagnosis of liver fibrosis in children with NAFLD has been developed.  Product Description popup.authors Zavgorodnyaya Natalya Yu Zigalo Elvira V. Kislova Raisa Mikolaivna Klenina Ina Anatoliivna Petishko Oksana P Tatarchuk Oksana M. popup.nrat_date 2023-01-24 Close