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Registration Number

0223U001268, 0122U001817 , R & D reports

Title

Development of new compounds for diagnostic and therapeutic applications in nuclear medicine and treatment of malignant tumors

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Head

Lampeka Rostyslav D., Доктор хімічних наук

Registration Date

26-01-2023

Organization

Taras Shevchenko National University of Kyiv

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Object of research: processes of obtaining new chelating and polynucleating ligands and coordination compounds of platinum group metals and transition metals based on them. The purpose of the work: development of preparative methods for the synthesis of new chelating agents and coordination compounds of platinum group metals and 3d metals based on polydentate organic ligands. Research methods: NMR, electron and IR spectroscopy, ESI mass spectrometry. Complex compounds of copper(II), palladium(II), platinum, and ruthenium were obtained by the reaction of chelating ligands and corresponding metal salts with their subsequent crystallization from the reaction mixture. The synthesized compounds were identified and characterized by spectral analysis methods (IR, UV, NMR, mass spectrometry). On the example of the simplest system of a 3,5-substituted triazole ligand, the formation of polynuclear linear ensembles of СuII and [Cu4(triazole)6], which are formed with the help of multicenter interactions, was recorded of organic ligands with metal centers into coordination frameworks (CuII-[N-N]-CuII) and supported by bridging inorganic anions. The main patterns of coordination of 3-pyridine-1,2,4-triazoles with cuprum(II) ion were revealed: ligands form mononuclear complexes when reacted with a metal in a ratio of 2:1, and binuclear complexes when reacted with a metal in a ratio of 1:1. It was also established that the anion of copper(II) salts does not affect the nuclearity of the structures. More significant for complexation is the substituent in the 5-position of the triazole ring, which affects the acidity of the triazole proton. So, for example, the electron-donating group -CH3 (methyl) leads to an increase in the basic properties of the ligand, which leads to an increase in the values of pKa1 and pKa2.

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Vashchenko Oleksandr V.
Doroschuk Roman O.
Zakharchenko Borys V.
Kazimirov Volodymyr P.
Plutenko Maksym O.
Raspertova Іlona V.
Khomenko Dmytro M.

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2023-01-26