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Registration Number

0223U001663, 0120U104348 , R & D reports

Title

Improvement of therapeutic diagnostic technologies and biosecurity measures of mono - and mixed tick - borne infection.

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Head

Andreychyn Mykhailo A., Доктор медичних наук

Registration Date

01-02-2023

Organization

I. Horbachevsky Ternopil State Medical University

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 Report on the GDR (interim): 97 pp., 21 pictures, 19 tables, 45 sources. LYME BORRELIOIS, IXODIC TICKS, B. BURGDORFERI SENSU LATO (B. BURGDORFERI SENSU STRICTO B. AFZELII AND B. GARINII, B. SPIELMANII), B MIYAMOTOI, A. PHAGOCYTOPHILUM, BABESIA SPP, BARTONELLA HENSELAE/QUINTANA, INTERLEUKINS, IMMUNOGLOBULINS, ERYTHEMATIC FORM OF LYME-BORRELIOSIS, NON-ERYTHEMATIC FORM OF LYME-BORRELIOSIS, NETTING, LOCALIZED SCLERODERMIA, IFA, IMMUNOBLOT, MULTIPLEX INDIRECT IMMUNOFLUORESCENCE, POLYMERASE CHAIN REACTION, THERMOGRAPHY. The object of the study: Ixodes ticks, selected from patients and from the environment of 5 parks of the city of Ternopil and 7 oblasts of Ukraine; patients with erythematous and non-erythematous form of Lyme borreliosis with damage to the cardiovascular (CSS), nervous system (NS) and musculoskeletal system (MS), localized scleroderma, urticaria; individuals who have been attacked by ticks infected with A. Phagocytophilum; pregnant women with pregnancy pathology. The purpose of the work: to establish the frequency of natural infection of ticks selected from people, animals and from the environment of 5 parks of the city of Ternopil and 7 oblasts of Ukraine: Ternopil, Lviv, Volyn, Rivne, Khmelnytskyi, Vinnytsia and Zhytomyr B. burgdorferi s. l., A. phagocytophilum, B. miyamotoi and Babesia spp.; to study clinical and epidemiological features and immune changes and to improve the results of treatment in patients with urticaria, including in the presence of concomitant Lyme borreliosis and giardiasis; to study the clinical, epidemiological and immunological features, as well as to improve the therapy of Lyme borreliosis in combination with localized scleroderma; apply the ELISA and immunoblot method EUROLINE Borrelia RN-AT adv to establish the involvement of pathogens.

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2023-02-01