Registration Number
0223U002057,
0122U001220
, R & D reports
Title
Synthesis of N,O,S-containing heterocycles and study of their interaction with nucleic acids
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Head
Okovytyi Serhii І., Доктор хімічних наук
Registration Date
07-02-2023
Organization
Oles Honchar Dnipro National University
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The subject of research is N,O,S-heterocycles, catalysts and ligands for asymmetric synthesis, supercoiled DNA, DNA and RNA oligonucleotides with non-canonical sequences. The object of research is in silico research, prediction of activity, modification and synthesis of N,O,S-heterocycles, interaction with DNA and RNA. The purpose of the work is the purposeful creation of new nucleotide-binding substances (ligands) in a number of N,O,S-heterocyclic compounds and the development of principles for their further use in medical practice. An analytical review of various sources of information on the interaction of organometallic compounds with nucleic acids, in particular platinum-containing and other organometallic compounds with DNA and plasmid, was conducted. Methods of syntheses of new N,O,S-heterocycles based on norbornene and endic anhydride have been developed. A computer-chemical analysis of previously synthesized N,O,S-heterocyclic compounds was carried out. The interaction of bis-dimethylsulfoxide-cis-tetrachlorodi-μ-pivalatodirhenium (III) with calf thymus DNA (CT DNA) and herring sperm (HS DNA) was studied. Field of application: synthetic organic and inorganic chemistry, biochemistry, computer analysis.
Product Description
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Anishenko Andrey O.
Borysenko Iryna O.
Gaponov Oleksandr O
Kopteva Svitlana D.
Okovytyy Sergii I.
Palchykov Vitalii O.
Stets Nadiia V
Shtemenko Natalia I.
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2023-02-07
