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Information × Registration Number 0223U002072, 0122U001810 , R & D reports Title Orbitally controlled reactions of carbo- and heterocycles for medical chemistry and sustainable development. popup.stage_title Head Voitenko Zoia V., Доктор хімічних наук Registration Date 07-02-2023 Organization Taras Shevchenko National University of Kyiv popup.description2 Research object: carbocycles, heterocycles, incl. nitrogen-containing (isoindoles, condensed isoindoles, their heteroanalogues, maleic and succinimides, other dienophiles, etc.) and oxygen-containing (chromones, oxadiazoles, etc.), amino acids, fluorine-containing compounds. The purpose of the work: development of approaches to the controlled synthesis of organic substances with specified properties for the needs of medical chemistry, agrochemistry, materials science, etc. Research methods: study by spectral and computer methods of the influence of various factors that determine the selectivity of the studied carbo-, heterocyclization and functionalization reactions (catalyst, solvent, temperature, electronic nature of substituents, steric factors, etc.). A method for the synthesis of 2-(3-pyrrolidin-1,2,4-oxadiazol-5-yl)-2,3-dihydro-4H-chromen-4-ones was found, in the molecule of which two pharmacophore fragments and a pyrrolidine fragment are simultaneously combined, which allows to significantly increase water solubility by forming the corresponding hydrochloride. Two catalytic systems have been developed for the arylboration of endocyclic enecarbamates to deliver synthetically versatile borylated saturated N-heterocycles in good regio- and diastereoselectivities. A Cu/Pd dual catalytic reaction enables the synthesis of borylated, -arylated azetidines, while a Ni-catalysed arylboration reaction efficiently functionalizes 5-, 6-, and 7-membered enecarbamates. In the case of the Cu/Pd-system, a remarkable additive effect was identified that allowed for broader scope. A strategy of approach to new derivatives of 1-bromocyclopentene was found. The selective functionalization of non-activated C(sp3)–H bonds within alkyl chains represents one of the major challenges in synthetic organic chemistry. Product Description popup.authors Kysil Аndriy І. Levkov Igor V. Lyubchuk Tetyana V. Mykhailiuk Pavlo K. popup.nrat_date 2023-02-07 Close