Registration Number
0223U002320,
0122U002126
, R & D reports
Title
Role of TRP channels in visceral nociception and impaired smooth muscle contractility evoked by general anesthetics
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Head
Galaidych Oleg V., Кандидат біологічних наук
Registration Date
15-02-2023
Organization
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
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We established that lamina X neurons of the rat spinal cord receive inputs from specific nociceptive afferents activated by TRPV1 receptors, which can be inhibited by activation of TRPM8 receptors. We investigated that the intravenous anesthetic ketamine inhibited calcium transients in ileal myocytes, which were restored by the selective agonist of TRPC4 channels, (-) Englerin A. The inhibitory effect of ketamine on carbachol-stimulated contractions of the mouse ileum was investigated using the method of tensometric recording of contractions. We also demonstrated that the anesthetic lidocaine suppresses the carbachol-induced contractile activity of the mouse small intestine.
Product Description
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Agashkov Kyrilo S.
Blaschak Ivan O.
Galaidych Oleg V.
Dryn Dariia O
Melʹnyk Mariya I.
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2023-02-15
