Registration Number
0223U002415,
0122U002451
, R & D reports
Title
Individualization of combined treatment of locally advanced cancer of the oral cavity and large salivary glands based on the study of molecular genetic and molecular biological markers of aggressiveness of the disease
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Head
Protsyk Volodymyr S., д.мед.н.
Registration Date
17-02-2023
Organization
National Cancer Institute
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The object of research is cancer of the oral cavity. The purpose of the work: to investigate the prognostic value of miRNA 21, -375 expression levels in patients with locally advanced oral cavity cancer. Research methods - general clinical, pathomorphological, endoscopic, radiation, polymerase chain reaction method. The expression levels of 21,375 miRNAs in the tumor tissue of 30 patients with locally advanced squamous cell carcinoma of the oral cavity were studied. The relationship between the expression indicators of microRNA 21 and -375 in the tumor tissue of patients with locally advanced squamous cell carcinoma of the oral cavity and the duration of the recurrence-free period was proved. The expression levels of miRNA 21 and -375 were 1.6 (p<0.05) and 2.4 (p<0.05) times lower in patients whose duration of the relapse-free period was < 12 months compared to patients whose duration of the relapse-free period was period was ≥ 12 months. The expression of miRNA 21 was associated with the prevalence of the primary tumor (p<0.05) and metastatic lesions of the cervical lymph nodes (p<0.05). An association of miRNA 375 expression with the degree of tumor differentiation (p<0.05) and metastatic lesions of cervical lymph nodes (p<0.05) was established. Efficiency: medical - increasing the share of radical operations, improving the immediate and long-term results of treatment; economic - reducing the length of stay of patients in the hospital, reducing the frequency of postoperative complications, disability of patients; social - improving the quality of life of patients.
Product Description
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Korobko Yevgen V.
Kravets Oleg V.
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2023-02-17
