Registration Number
0223U002437,
(0122U002452)
, R & D reports
Title
To develop radionuclide and cytological determinants for evaluating the effectiveness of targeted therapy of iodine-negative metastases of differentiated thyroid cancer
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Впровадити методику лікування препаратами інгібіторами тирозинкінази йод-негативних метастазів диференційованого раку щитовидної залози
Head
Solodiannykova Oksana I., д.мед.н.
Registration Date
21-02-2023
Organization
National Cancer Institute
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Develop methods for evaluating the effectiveness of treatment of iodine-negative metastases of differentiated thyroid cancer with tyrosine kinase inhibitors
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The object of the study is 28 patients with iodine-negative metastases of differentiated thyroid cancer. The purpose of the work is to develop a method of treatment of iodine-negative metastases of differentiated thyroid cancer with the help of tyrosine kinase inhibitors and to determine the significance of radionuclide determinants in the assessment of effectiveness. Research methods and equipment – scintigraphy of the whole body with 99mTc-MIBI; whole body scintigraphy with 99mTc-DMCA; positron emission tomography with 18F-FDG; methods of statistical processing of results; two-detector gamma camera of the company "Mediso" (Hungary), single-photon emission computed tomography (SPECT) "E. CAM 180”. 28 patients with differentiated thyroid cancer were examined, 10 of them, treated with the targeted drug sorafenib, underwent SVT with 99mTc-MIBI in order to assess the therapeutic effectiveness by scintigraphic imaging. A method of treatment with drugs, tyrosine kinase inhibitors, of iodine-negative metastases of DSCLC has been developed. In 10 patients with differentiated thyroid cancer and iodine-negative metastases, a scintigraphic evaluation of the effectiveness of treatment using PET with 18F-FDG was performed. In 8 patients, in whom bone damage was detected, treatment was carried out with the help of radionuclide and remote radiation therapy. Control of treatment effectiveness was carried out using SVT with 99mTc-MDR.
Product Description
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Sukach Heorhii H.
Dzhuzha Dmytro O.
Danylenko Viktoriia V.
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2023-02-21
