Registration Number
0223U003335,
0121U111879
, R & D reports
Title
To investigate the course of arterial hypertension and target organ damage in patients with comorbid pathology on the background of COVID-19
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Head
Mishchenko Larysa А., д.мед.н.
Talaieva Tetiana V., д.мед.н.
Registration Date
20-04-2023
Organization
State Institution "National Scientific Center "The M.D. Strazhesko Institute of cardiology, clinical and regenerative medicine named after academician of the National Academy of Medical Sciences of Ukraine"
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The relationship of COVID-19 and target-organs damage in arterial hypertension patients and comorbid pathology have nature of a vicious circle. In this category of patients with comorbidities, like a cardiovascular disease, diabetes mellitus, obesity, the activation of the sympathetic nervous system is already is a background and in COVID-19 patients leading to lesion of the heart and vessels. By itself COVID-19 leads to hypoxia and to an active immune response, also causing activation of the sympathetic nervous system.
A lower left ventricular ejection fraction and moderate right ventricular dilatation occur in patients with hypertension who developed mild to moderate COVID-19 after an average of 1.2 ± 0.3 years.
In patients with COVID-19, an increased ability of platelets to interact with monocytes, neutrophils and endotheliocytes was found, as evidenced by a tendency to increase the expression of P-selectin on platelets and the percentage of platelets bearing P-selectin on their surface, as well as a decrease of the regenerative capacity of the endothelium, as indicated by a certain decrease in the number of cells-precursors of endotheliocytes.
The obtained data indicate that the war in Ukraine has a negative effect on the blood pressure level of patients with hypertension, complicates the possibility of optimizing their treatment, and also contributes to the increase of blood pressure in normotensive patients.
Product Description
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Bezrodna Larysa
Bezrodnyi Volodymyr
Bozhenko Galyna
Gulkevych Oksana Volodymyrivna
Kupchynska Olena H.
Matova Olena
Pidhaina Olena A.
Radchenko Volodymyr
Rudya Ganna
Sylka Lyudmyla
Tretiak Iryna V.
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2023-04-20
