Registration Number
0223U003402,
0120U101352
, R & D reports
Title
Methods of synthesis and prediction for the pharmacological activity of nitrogen-containing heterocycles.
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Head
Kharchenko Oleksandr V., Доктор хімічних наук
Registration Date
26-04-2023
Organization
Ukrainian State University of Chemical Technology
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The object of research is derivatives of thieno[2,3-d]pyrimidines; ?-glucuronidase inhibitors; xanthene phosphors, Cu(Zn)-containing catalysts, arenalazines of 1,4-benzoquinone. The purpose of the work is the development of new methods of synthesis of biologically active substances and prediction of pharmacological activity using computer modeling. The research methods are chemical synthesis, thin-layer chromatography (TLC), X-ray structural analysis (XRA), infrared spectroscopy (IR) and nuclear magnetic resonance (NMR) spectroscopy, ultraviolet spectroscopy (UV), mass spectrometry and quantum chemical calculations. Developed: synthesis method of new substituted thieno[2,3-d]pyrimidin-4(3H)-ones; the method of acylamination of N-arylsulfonyl-1,4-benzoquinonimines with derivatives of O-acylbenzhydroxamic acids with the formation of o-hydroxyphenyl derivatives of pyrazoles. The field of use of the work results is C 20.20 production of pesticides and other agrochemical products, C 21.10 production of basic pharmaceutical products.
Product Description
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Bilov Volodymyr V.
Varenychenko Svitlana A.
Zadorozhnii Pavlo V.
Karpishchenko Liudmyla S.
Kyselov Vadym V.
Kryshchyk Oksana V.
Lomynoha Olena O.
Markov Viktor I.
Okhtina Oksana V.
Paramonova Tetiana H.
Prosianyk Oleksandr V.
Sokolova Lina O.
Farat Oleh K.
Kharchenko Oleksandr V.
Shtamburh Vasylii H.
Yakymenko Ihor Y.
Yanova Karolina V.
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2023-04-26
