Registration Number
0223U003463,
0120U101957
, R & D reports
Title
Synthesis of rhenium compounds with antioxidant and luminescent properties and research of their specific interaction with biological molecules.
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Head
Shtemenko Oleksandr V., Доктор хімічних наук
Registration Date
11-05-2023
Organization
Ukrainian State University of Chemical Technology
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The object of study are physico-chemical and biological properties compounds of Re(III) and Re(I). The aim of the work is the obtain a complex of next experimental data: the interaction of dirhenium(III) aminoacid compounds with G4-quadruplexes; the determination of the effect of the structure of rhenium complex compounds on their antiradical and antioxidant properties; the study of the influence on the configuration and properties of biological macromolecules (catalase, albumin) by rhenium(III) complex compounds obtained; the determination of quantum yield intensity and luminescence lifetime for carbonyl rhenium(I)complexes; the study of the stability of synthesized compounds in conditions close to physiological ones; the determination of the effectiveness of rhenium(I) compounds modified as biomarkers. Research methods -physicochemical methods, electrical conductivity, electronic, nuclear magnetic resonance (NMR) and infrared (IR) -spectroscopy. The interaction of rhenium(III) cluster compounds was studied with: G4-quadruplexes; radicals; biological macromolecules (catalase, albumin); physiological solutions. For the carbonyl complexes of rhenium(I): the intensity of the quantum yield and the lifetime of luminescence were established; the efficacy was determined as biomarkers. Field of use: C 20.59 Manufacture of other chemical products; C 21.20 Manufacture of pharmaceutical preparations and materials; P 85.42 Higher education; Q 86.90 Other health care activities.
Product Description
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Bilenka Zhanna V.
Berzenina Oksana V.
Velychko Olena V.
Holichenko Oleksandr A.
Kytova Dina Y.
Malook Maksym V.
Panteleieva Olha S.
Shtemenko Nataliia I.
Shtemenko Oleksandr V.
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2023-05-11
