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Information × Registration Number 0223U003562, 0120U102025 , R & D reports Title Prediction of the flowing, improvement of diagnosis and treatment of ischemic heart disease and arterial hypertension in patients with metabolic disorders popup.stage_title Head Kravchun Pavel G., д.мед.н. Registration Date 24-05-2023 Organization Kharkiv National Medical University popup.description2  In patients with acute myocardial infarction and accompanying obesity, arterial hypertension, and type 2 diabetes, an increase in FABP 4 and a decrease in adropin and irisin are determined, which indicates an imbalance of energy homeostasis and the adipokine system. The presence of acute myocardial infarction in patients with obesity, arterial hypertension, and type 2 diabetes mellitus was associated with low levels of CTRP 3 compared to patients without obesity, arterial hypertension, and type 2 diabetes mellitus, indicating increased activity of the adipokine system. Analyzing the indicators of endothelial dysfunction in relation to mortality, the following can be determined: the EMAP-II value greater than 3.44 ng/ml predicts the probability of cardiovascular death within a 6-month period. ADMA shows predictive qualities in relation to the development of acute left ventricular failure when the indicator value is > 1.13 μmol/l; to the development of cardiogenic shock at a value > 2.08 μmol/l during the hospital period of acute myocardial infarction with ST segment elevation in patients with polymorbidity. An increase in the degree of expression of insulin resistance in patients with acute myocardial infarction and concomitant type 2 diabetes, obesity and arterial hypertension in the dynamics of observation depending on different types of treatment and associated with a decrease in the levels of FABP 4 and an increase in the levels of irisin, adropin, CTRP 3, which is confirmed the negative impact of hyperinsulinemia, hyperglycemia, and impaired tissue glucose tolerance on the structural and functional state of the endothelium and myocardium. Product Description popup.authors Babadzhan Volodymyr D. Borovyk Kateryna Mykolayivna Gridneva Olga V. Dobrovolska Iryna M. Zaikina Tetiana Serhiivna Zaliubovska Olha Illivna Kadykova Ol'ga Igorivna Koval'ova Yuliya Oleksiyivna Kozhyn Myhailo I. Koteliukh Mariia Yu. Mozgova Yuliya Mykolayivna Rylova Maria O. Ryndina Nataliia G. Rynchak Petro Ivanovych Sypalo Anna Olegivna Feldman Diana A. Shekest Oleksiy M. popup.nrat_date 2023-05-24 Close