Registration Number
0223U003562,
0120U102025
, R & D reports
Title
Prediction of the flowing, improvement of diagnosis and treatment of ischemic heart disease and arterial hypertension in patients with metabolic disorders
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Head
Kravchun Pavel G., д.мед.н.
Registration Date
24-05-2023
Organization
Kharkiv National Medical University
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In patients with acute myocardial infarction and accompanying obesity, arterial hypertension, and type 2 diabetes, an increase in FABP 4 and a decrease in adropin and irisin are determined, which indicates an imbalance of energy homeostasis and the adipokine system. The presence of acute myocardial infarction in patients with obesity, arterial hypertension, and type 2 diabetes mellitus was associated with low levels of CTRP 3 compared to patients without obesity, arterial hypertension, and type 2 diabetes mellitus, indicating increased activity of the adipokine system. Analyzing the indicators of endothelial dysfunction in relation to mortality, the following can be determined: the EMAP-II value greater than 3.44 ng/ml predicts the probability of cardiovascular death within a 6-month period. ADMA shows predictive qualities in relation to the development of acute left ventricular failure when the indicator value is > 1.13 μmol/l; to the development of cardiogenic shock at a value > 2.08 μmol/l during the hospital period of acute myocardial infarction with ST segment elevation in patients with polymorbidity. An increase in the degree of expression of insulin resistance in patients with acute myocardial infarction and concomitant type 2 diabetes, obesity and arterial hypertension in the dynamics of observation depending on different types of treatment and associated with a decrease in the levels of FABP 4 and an increase in the levels of irisin, adropin, CTRP 3, which is confirmed the negative impact of hyperinsulinemia, hyperglycemia, and impaired tissue glucose tolerance on the structural and functional state of the endothelium and myocardium.
Product Description
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Babadzhan Volodymyr D.
Borovyk Kateryna Mykolayivna
Gridneva Olga V.
Dobrovolska Iryna M.
Zaikina Tetiana Serhiivna
Zaliubovska Olha Illivna
Kadykova Ol'ga Igorivna
Koval'ova Yuliya Oleksiyivna
Kozhyn Myhailo I.
Koteliukh Mariia Yu.
Mozgova Yuliya Mykolayivna
Rylova Maria O.
Ryndina Nataliia G.
Rynchak Petro Ivanovych
Sypalo Anna Olegivna
Feldman Diana A.
Shekest Oleksiy M.
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2023-05-24
