Registration Number
0223U003570,
0118U000940
, R & D reports
Title
The pharmacological study of potential medicinal drugs containing biologically active substances of natural origin
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Head
Yermolenko Tamara I., Доктор фармацевтичних наук
Registration Date
25-05-2023
Organization
Kharkiv National Medical University
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A study was carried out and it was established that the thick extract of carrot roots (GEKM) and the thick extract of parsnip roots (GE-KP) are safe, have an anti-inflammatory effect due to anti-exudative properties, have a significant wound-healing effect and membrane-protective activity, which are one of the links of their wound-healing effect and are promising for further study in order to create new drugs. It is shown that Wundehil ointment exhibits a more pronounced anti-burn effect compared to Spasatel-forte and thiotriazoline 2% ointments, which allows them to be effectively used in the treatment of superficial burn wounds and as reference drugs in the experiment. It has been proven that REPS and 40% alcohol tincture of burdock root exhibit significant diuretic, hypouroco-suric, membrane-stabilizing and hemodilution properties and can be recommended for the creation of new RLZ for the treatment of gout. It has been shown that SNHV has a significant anti-inflammatory and analgesic effect, pronounced gastroprotective properties and does not affect intestinal peristalsis and is promising for further research with the aim of creating a new RLZ for gastroenterology. A more pronounced membrane-protective, anti-inflammatory, analgesic and gastroprotective effect of the drug "Lisichky-drops" compared to the drug "Shiitake-drops" was established. It has been proven that the infusion of Tagetes flowers is safe (LD50 not established) and exhibits significant membrane-protective properties and can be recommended for further pharmacological study. It was shown that corvalol and novo-pasit in the "open field" test suppressed the emotional component and did not affect locomotor and research activity. With long-term immobilization stress, corvalol and novopasit decreased the mass coefficient of the adrenal glands, which indicates a stress-protective effect. Corvalol and novopasit reduced damage to the gastric mucosa against the background of stress due to stress protection.
Product Description
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Pautina Olena I.
Ruda Natalia G.
Chorna Nataliya Stepanivna
Shapoval Ol'ga Mykolayivna
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2023-05-25
