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Information × Registration Number 0223U005302, 0123U103366 , R & D reports Title Non-covalent complexes of water-insoluble drugs with synthetic nanomicelles for their delivery and enhancement of biological activity popup.stage_title Head Zaichenko Oleksandr S., Доктор хімічних наук Registration Date 19-12-2023 Organization Lviv Polytechnic National University popup.description2 The colloidal-chemical characteristics of polyamphiphiles of complex architecture, in particular with PEG- and polyoxazoline chains, have been investigated in detail. The regularities of morphology and size of micellar structures from the structure, molecular weight and nature of grafted chains of the obtained polyamphiphiles have been established. Methodological approaches for the formation of supramolecular complexes of polymers of block, branched and block-branched structure with Berberine and its alkylated derivative have been developed. The optimal conditions, namely pH value, temperature, polymer carrier: alkaloid ratio, for the formation of stable aqueous delivery systems of alkaloids were determined. Complexes of the developed carriers with Berberine and its alkyl derivative were studied in delivery systems to cells and tissues. Dependences of their general toxicity and therapeutic efficacy on the structure and functionality of polymers, morphology, size and charge of micellar complexes were investigated, which is important for control of chemotherapy efficacy. It was shown that the optimal structure for creating an effective delivery system based on alkaloids is polymeric nostels of branched architecture with grafted PEG or polymethyloxazoline branches.   Product Description popup.authors Izhyk Oleh Harhay Khrystyna Mitina Nataliya Stetsyshyn Yurii Stoika Rostyslav Finiuk Nataliya popup.nrat_date 2023-12-19 Close