Registration Number
0223U005302,
0123U103366
, R & D reports
Title
Non-covalent complexes of water-insoluble drugs with synthetic nanomicelles for their delivery and enhancement of biological activity
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Head
Zaichenko Oleksandr S., Доктор хімічних наук
Registration Date
19-12-2023
Organization
Lviv Polytechnic National University
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The colloidal-chemical characteristics of polyamphiphiles of complex architecture, in particular with PEG- and polyoxazoline chains, have been investigated in detail.
The regularities of morphology and size of micellar structures from the structure, molecular weight and nature of grafted chains of the obtained polyamphiphiles have been established. Methodological approaches for the formation of supramolecular complexes of polymers of block, branched and block-branched structure with Berberine and its alkylated derivative have been developed. The optimal conditions, namely pH value, temperature, polymer carrier: alkaloid ratio, for the formation of stable aqueous delivery systems of alkaloids were determined. Complexes of the developed carriers with Berberine and its alkyl derivative were studied in delivery systems to cells and tissues. Dependences of their general toxicity and therapeutic efficacy on the structure and functionality of polymers, morphology, size and charge of micellar complexes were investigated, which is important for control of chemotherapy efficacy. It was shown that the optimal structure for creating an effective delivery system based on alkaloids is polymeric nostels of branched architecture with grafted PEG or polymethyloxazoline branches.
Product Description
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Izhyk Oleh
Harhay Khrystyna
Mitina Nataliya
Stetsyshyn Yurii
Stoika Rostyslav
Finiuk Nataliya
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2023-12-19
