Registration Number
0223U005308,
0123U102648
, R & D reports
Title
Structurally modified natural compounds of the bromotyrosine series as inhibitors of bacterial biofilms for the prevention and treatment of persistent infections
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Head
Smolii Oleh B., д.х.н.
Registration Date
19-12-2023
Organization
V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
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The approaches to the synthesis of new functionally substituted derivatives of 3,5-dibromo-4-hydroxyphenylacetic acid – structural analogues of natural compounds of the bromotyrosine series – were developed for the first time, and the antimicrobial action of the obtained structurally modified derivatives as inhibitors of bacterial biofilms was evaluated. Based on 3,5-dibromo-4-hydroxyphenylacetic acid derivatives, new analogues of pulmonarin were synthesized for the first time and their antibacterial and antibiofilm activity against S. aureus 222, E. coli 311 and P. aeruginosa 449 was evaluated. An effective method for the synthesis of new pyrimidin-5-yltriphenylphosphonium-containing analogues of bromotyrosine was discovered, and the compounds with pronounced activity against planktonic and biofilm gram-positive (S. aureus) and gram-negative (P. aeruginosa, E. coli) microorganisms were found.
Product Description
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Vrynchanu Nina O.
Humeniuk Nataliya I.
Muzychka Liubov V.
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2023-12-19
