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Information × Registration Number 0223U005507, 0123U102781 , R & D reports Title Cellular and molecular mechanisms of vitamin D3 hepatoprotective action in non-alcoholic fatty liver disease associated with experimental type 2 diabetes mellitus popup.stage_title Head Shymanskyi Ihor O., Кандидат біологічних наук Registration Date 23-12-2023 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description2  It has been shown that experimental type 2 diabetes in rats is accompanied by the development of insulin resistance, hyperglycemia, and disorders of lipid (dyslipidemia) and protein metabolism. The dependence of metabolic changes in diabetes with the development of vitamin D deficiency and biochemical and histological signs of nonalcoholic fatty liver disease (NAFLD) has been demonstrated. The study of molecular and cellular mechanisms of NAFLD development in type 2 diabetes revealed intensification of oxidative-nitrosative/genotoxic stress, endoplasmic reticulum stress and increased autophagy in liver tissue. This is accompanied by changes in mitochondrial dynamics (an increase in MFN1- and MFN2-mediated fusion as well as Fis1-associated fission) as a possible mechanism of bioenergetic adaptation to the metabolic needs of the cell. The effectiveness of the therapeutic administration of cholecalciferol in the correction of disorders associated with the development of NAFLD in T2DM has been demonstrated. Product Description popup.authors Goridko Tetyana Mykolaivna Kuchmerovska Tamara M. Lisakovska Olha O. Labudzynskyi Dmytro O. Mezhenska Olha Olexandrivna Pasichna Elvira Pavlivna Siromolot Andriy A. Tykhonenko Tetiana M. popup.nrat_date 2023-12-23 Close