Registration Number
0223U005507,
0123U102781
, R & D reports
Title
Cellular and molecular mechanisms of vitamin D3 hepatoprotective action in non-alcoholic fatty liver disease associated with experimental type 2 diabetes mellitus
popup.stage_title
Head
Shymanskyi Ihor O., Кандидат біологічних наук
Registration Date
23-12-2023
Organization
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine
popup.description2
It has been shown that experimental type 2 diabetes in rats is accompanied by the development of insulin resistance, hyperglycemia, and disorders of lipid (dyslipidemia) and protein metabolism. The dependence of metabolic changes in diabetes with the development of vitamin D deficiency and biochemical and histological signs of nonalcoholic fatty liver disease (NAFLD) has been demonstrated. The study of molecular and cellular mechanisms of NAFLD development in type 2 diabetes revealed intensification of oxidative-nitrosative/genotoxic stress, endoplasmic reticulum stress and increased autophagy in liver tissue. This is accompanied by changes in mitochondrial dynamics (an increase in MFN1- and MFN2-mediated fusion as well as Fis1-associated fission) as a possible mechanism of bioenergetic adaptation to the metabolic needs of the cell. The effectiveness of the therapeutic administration of cholecalciferol in the correction of disorders associated with the development of NAFLD in T2DM has been demonstrated.
Product Description
popup.authors
Goridko Tetyana Mykolaivna
Kuchmerovska Tamara M.
Lisakovska Olha O.
Labudzynskyi Dmytro O.
Mezhenska Olha Olexandrivna
Pasichna Elvira Pavlivna
Siromolot Andriy A.
Tykhonenko Tetiana M.
popup.nrat_date
2023-12-23
