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Information × Registration Number 0223U005595, 0122U000081 , R & D reports Title 640. To investigate the chronic convulsive syndrome pathogenetic mechanisms on the model of pharmacological kindling and to study the efficacy of its complex pathogenetical correction by anticonvulsant mechanisms activation popup.stage_title Head Vastianov Ruslan S., д.мед.н. Registration Date 25-12-2023 Organization Odessa National Medical University popup.description2 It was established that opioid mechanisms prevailed in the structure of late tonic behavioral reactions of animals during the formation of picrotoxin-induced chronic convulsive syndrome. At the time neuroleptic components prevail in the structure of late tonic behavioral reactions of animals in conditions of developed picrotoxin kindling. Opioid mechanisms prevail in the structure of late tonic behavioral reactions of animals at the end of the seizure-free period after the 14-day interval after the end of kindling. In rats, in the dynamics of picrotoxin-induced kindling, violations of late-tonic behavior and swimming behavior, which are correlates of non-convulsive behavior, are registered. The revealed violations of non-convulsive types of behavior progressed in the dynamics of the formation of the kindling model of epilepsy and were maximal at the stages of completed kindling and in the post-kindling stage. The study of nonconvulsive varieties of motor and swimming behavior and their disorders during the marked time intervals of the formation of chronic epileptic activity is important for the use of determined behavioral activity disorders as an early diagnosis of the manifestation of epilepsy, when motor convulsive manifestations are absent, and probable behavioral disorders do not acquire maximum intensity.   Product Description popup.authors Vastyanov Rooslan Kirchev Vladyslav Kolesnychenko Olena Krepec Yuliya Lapshym Dmytrpo Myronov Oleksandr Ostapenko Ihor Sadovyi Oleksandr Sarakhan Vasyl Stoyanov Oleksandr Topal Maryna popup.nrat_date 2023-12-25 Close