Registration Number
0223U005595,
0122U000081
, R & D reports
Title
640. To investigate the chronic convulsive syndrome pathogenetic mechanisms on the model of pharmacological kindling and to study the efficacy of its complex pathogenetical correction by anticonvulsant mechanisms activation
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Head
Vastianov Ruslan S., д.мед.н.
Registration Date
25-12-2023
Organization
Odessa National Medical University
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It was established that opioid mechanisms prevailed in the structure of late tonic behavioral reactions of animals during the formation of picrotoxin-induced chronic convulsive syndrome. At the time neuroleptic components prevail in the structure of late tonic behavioral reactions of animals in conditions of developed picrotoxin kindling. Opioid mechanisms prevail in the structure of late tonic behavioral reactions of animals at the end of the seizure-free period after the 14-day interval after the end of kindling.
In rats, in the dynamics of picrotoxin-induced kindling, violations of late-tonic behavior and swimming behavior, which are correlates of non-convulsive behavior, are registered. The revealed violations of non-convulsive types of behavior progressed in the dynamics of the formation of the kindling model of epilepsy and were maximal at the stages of completed kindling and in the post-kindling stage.
The study of nonconvulsive varieties of motor and swimming behavior and their disorders during the marked time intervals of the formation of chronic epileptic activity is important for the use of determined behavioral activity disorders as an early diagnosis of the manifestation of epilepsy, when motor convulsive manifestations are absent, and probable behavioral disorders do not acquire maximum intensity.
Product Description
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Vastyanov Rooslan
Kirchev Vladyslav
Kolesnychenko Olena
Krepec Yuliya
Lapshym Dmytrpo
Myronov Oleksandr
Ostapenko Ihor
Sadovyi Oleksandr
Sarakhan Vasyl
Stoyanov Oleksandr
Topal Maryna
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2023-12-25
