Registration Number
0223U005801,
0121U112051
, R & D reports
Title
To determine the effectiveness of hormonotherapy in the complex treatment of patients with ovarian cancer or its recurrences.
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Head
Mikhanovskyi Oleksandr A., Доктор медичних наук
Sukhina Olena M., Доктор медичних наук
Registration Date
31-12-2023
Organization
State Organization "Grigoriev Institute for Medical Radiologiy and Oncology of the National Academy of Medical Sciences of Ukraine"
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Object of research: treatment of patients with ovarian cancer. The purpose of the study: to increase the effectiveness of complex treatment of ovarian cancer and recurrences of the disease by using hormone therapy based on the study of the level of expression of estrogen and progesterone receptors in the tumor and the content of sex hormones in the blood of patients. Research methods: clinical-instrumental, clinical, radiological, immunological, morphological, statistical. Theoretical and practical results: the theoretical result is the establishment of a relationship between the expression of MBM and the receptor status of the tumor in patients with OC. Moderate expression of Ki67 was determined in the majority of patients with OC (53.0%), regardless of the receptor status of the tumor. In patients with ER+ PR+ and ER− PR+ progesterone levels, the frequency of expression of positive Bcl2 was 2–2.5 times more frequent than that of negative Bcl2. In patients with estrogen-positive (ER+ PR−) and estrogen-negative (ER− PR+) tumor receptor status, positive expression of VEGF was determined 1.9–6 times more often. In patients with estrogen-positive (ER+ PR−) and estrogen-negative (ER− PR−, ER− PR+ ) tumor receptor status, negative expression of p53 was more often determined. The practical result - the method of treatment of ovarian cancer patients with estrogen-positive receptor status of the tumor, who were prescribed continuous anti-estrogen therapy with drugs - letrazol, tamoxifen or examimtan, was improved. Novelty: For the first time, ovarian cancer patients with estrogen-positive tumor receptor status (ER+ PR-, ER+ PR+) were prescribed continuous anti-estrogen therapy to prolong the relapse-free period and treat relapses. Effectiveness of implementation: none. Field of application: oncology.
Product Description
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Artamonova Neonila Olehivna
Dolhaia Oksana Volodymyrivna
Kantsedal Olena Mykolaivnа
Krugova Iryna Mykolaivna
Lanko Liliia Hryhorivna
Lukashkova Olha Petrivna
Moiseienko Yuliia Anatoliivna
Muzhychuk Oleksij Volodymyrovych
Starikov Volodymyr Ivanovich
Teplova Maryna Anatoliivna
Teslenko Iryna Mykolaivna
Kharchenko Yuliia Volodymyrivna
Shchyt Nataliia Mykolaivna
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2023-12-31
