Registration Number
0224U000210,
0122U200746
, R & D reports
Title
Study the patterns of functional and structural brain changes in the clean-up workers of Chornobyl NPP accident in a remote post-accident period and in persons exposed to radiation under different scenarios of exposure in the state of martial law in Ukraine
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Head
Dykan Iryna M., д.мед.н., професор
Sushko Viktor O.,
Registration Date
03-01-2024
Organization
State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine"
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The study object is the neuropsychiatric, neuropsychological, clinical-radiological, and neurophysiological characteristics of 152 people, of which 57 are clean-up workers of the Chornobyl accident, 58 Chernobyl NPP workers, 37 non-irradiated people with cerebral small vessels disease. The aim of the study is to conduct neuropsychiatric, neurophysiological, neuropsychological, clinical and radiological studies to determine the cerebral effects after exposure to ionizing radiation under different exposure scenarios and their differences from chronic cerebrovascular disease (small vessel disease of the brain) in unexposed individuals. To evaluate the role of neurophysiological and structural changes in the white matter of the brain in the pathogenesis of radiation-associated brain damage. Methods: clinical, psychodiagnostic, neuropsychological, radiological, neurophysiological, statistical. In the Chernobyl clean-up workers signs of organic brain damage were found, with the predominant involvement of the cortico-limbic system of the left (dominant) hemisphere, a violation of information and cognitive processes of the brain against the background of functional hypofrontality. An excess of stress-related and somatoform disorders, mainly due to post-traumatic stress disorder, was found in the Chernobyl NPP workers who were under occupation. Signs of hyperactivation of the cortico-limbic system, mainly of the right (subdominant) hemisphere, physiological hyperexcitability of the main sensory systems, functional hypofrontality, which is most likely a psychophysiological response to prolonged psychoemotional stress, were revealed. MRI can detect early signs of structural changes in the white matter of the brain. The effect of IR under different radiation scenarios on the course of cerebral small vessel disease is realized in the form of more active processes of disorganization of the white matter of the brain.
Product Description
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Antypchuk Kateryna
Kolotylov Mykola M.
Kreinis Georgy Yu.
Kuts Kostiantyn
Perchuk Iryna
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2024-01-03
