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Information × Registration Number 0224U000285, 0119U002511 , R & D reports Title Study of receptors involved in the regulation of immunobiological functions of organism. popup.stage_title Head Komisarenko Serhii V., Доктор біологічних наук Registration Date 04-01-2024 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description2 New data were obtained regarding the mechanisms of nAChR action in mitochondria, nucleus, and synaptic vesicles, as well as the role of α7 nAChR in the development of inflammation and neurodegeneration in mice transgenic for β-amyloid and presenilin precursor genes; features of the proHB-EGF functions in modified cells and prospects for the use of recombinant diphtheria toxin derivatives and antibodies against HB-EGF as antitumor agents; mechanisms of interaction between antigens and specific antibodies or polyreactive immunoglobulins; production of recombinant MCP-1 protein with N14Q mutation and study of its citrullinated form stability; as well as dissemination of knowledge and international standards in the field of biosafety, biosecurity, and bioethics among specialists involved in medical and biological research. The results of the work can be used to find ways to prevent and treat Alzheimer's disease; develop new anticancer drugs; assess the affinity of antibodies contained in vivo in the mixture; improve the diagnosis of rheumatoid arthritis; improve the system of dissemination of biosafety and biosecurity knowledge in Ukraine.  Product Description popup.authors Izmailov Mykhailo Rustenovych Bobrovnyk Serhiy Panasovych Galkin Oleksandr Yuriiovych Gergalova Galyna Mykolayvna Goroshnikova Tamara Viktorivna Demchenko Myroslava Olexandrivna Zukova Darya Andriivna Kalashnyk Olena Mykolaivna Katashinskaya Daryna O. Koval Lyudmyla Mykolayivna Kozadayeva Yevgenia Oleksandrivna Kolybo Denys V. Korchynskiy Oleksandr H. Krynina Olha I. Kuklina Tetiana Oleksandrivna Kulyk Yaroslava S. Labintsev Andriy Yu. Lykhmus Olena Yuriyivna Maksymovych Iaroslava Sergiivna Manoilov Kyrylo Yuriyovych Romanyk Svitlana I. Siromolot Andrii A. Skok Marina V. Tykhonenko Tetiana M. Uspenska Kateryna Romanivna popup.nrat_date 2024-01-04 Close