Registration Number
0224U000285,
(0119U002511)
, R & D reports
Title
Study of receptors involved in the regulation of immunobiological functions of organism.
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Вивчення рецепторів, залучених до регуляції імунобіологічних функцій організму.
Head
Komisarenko Serhii V., Доктор біологічних наук
Registration Date
04-01-2024
Organization
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine
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New data were obtained regarding the mechanisms of nAChR action in mitochondria, nucleus, and synaptic vesicles, as well as the role of α7 nAChR in the development of inflammation and neurodegeneration in mice transgenic for β-amyloid and presenilin precursor genes; features of the proHB-EGF functions in modified cells and prospects for the use of recombinant diphtheria toxin derivatives and antibodies against HB-EGF as antitumor agents; mechanisms of interaction between antigens and specific antibodies or polyreactive immunoglobulins; production of recombinant MCP-1 protein with N14Q mutation and study of its citrullinated form stability; as well as dissemination of knowledge and international standards in the field of biosafety, biosecurity, and bioethics among specialists involved in medical and biological research. The results of the work can be used to find ways to prevent and treat Alzheimer's disease; develop new anticancer drugs; assess the affinity of antibodies contained in vivo in the mixture; improve the diagnosis of rheumatoid arthritis; improve the system of dissemination of biosafety and biosecurity knowledge in Ukraine.
Product Description
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Izmailov Mykhailo Rustenovych
Bobrovnyk Serhiy Panasovych
Galkin Oleksandr Yuriiovych
Gergalova Galyna Mykolayvna
Goroshnikova Tamara Viktorivna
Demchenko Myroslava Olexandrivna
Zukova Darya Andriivna
Kalashnyk Olena Mykolaivna
Katashinskaya Daryna O.
Koval Lyudmyla Mykolayivna
Kozadayeva Yevgenia Oleksandrivna
Kolybo Denys V.
Korchynskiy Oleksandr H.
Krynina Olha I.
Kuklina Tetiana Oleksandrivna
Kulyk Yaroslava S.
Labintsev Andriy Yu.
Lykhmus Olena Yuriyivna
Maksymovych Iaroslava Sergiivna
Manoilov Kyrylo Yuriyovych
Romanyk Svitlana I.
Siromolot Andrii A.
Skok Marina V.
Tykhonenko Tetiana M.
Uspenska Kateryna Romanivna
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2024-01-04
