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Information × Registration Number 0224U000473, 0119U002509 , R & D reports Title Molecular mechanisms of regulation and multidirectional modulation of the transport of excitatory and inhibitory neurotransmitters in the presynapse in norm and neuropathology popup.stage_title Head Borysova Tetiana O., Доктор біологічних наук Registration Date 08-01-2024 Organization Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine popup.description2 The results are essential for solving current problem regarding the mechanisms that determine the transport vector of neurotransmitters through the plasma membrane of the presynapse; the role of the structural organization of the membrane in the regulation of nerve impulse transmission; the role of presynaptic receptors in the regulation of key stages of neurotransmission and determining the ways of modulation of the neurotransmitter reception system; analysis of the molecular mechanisms of action of existing and new membranotropic and neuroactive drugs and create a biochemical basis and open ways to overcome neurological disorders. In the framework of nanoneurotoxicology research direction, the functional state of the exocytosis system, the transporter-mediated accumulation/release of neurotransmitters in the nerve terminals of the rat brain, and the ion-conducting properties of the planar phospholipid bilayer under the influence of various types of nano- and micro-particles were studied. Gadolinium-containing nanohybrids AGuIX with a proven ability to treat brain metastases did not show a neurotoxic effect, in contrast to their components. The ability of nanodiamonds to facilitate the ion transport through the lipid bilayer by forming ion-conducting channels in bilayer phospholipid membranes was determined. A unique compound, a derivative of 4-thiozolidinone, capable to modulate in the opositely directional manner the processes of excitation and inhibition in the nerve terminals of the brain was identified. Using a cell-free system that reproduces the stage of the compound exocytosis - the fusion of homotypic membranes, it was shown that after oral administration of the antiepileptic drug levetiracetam, the calcium-dependent fusion of synaptic vesicles decreased. The cationic biocide polyhexamethyleneguanidine hydrochloride caused a dose-dependent depolarization of the plasma membrane of brain nerve terminals and platelets and formed K+-selective potential... Product Description popup.authors Borisov Arseniy A Dudarenko Marina Volodymyrivna Kanyuk Mykola Igorovych Kasatkina Ludmila Olexandrivna Krisanova Natalia Valeriivna Nazarova Anastasiya Georgiyivna Panas Ihor Dankovych Pastukhov Artem Olegovych Pyrshev Kyrylo O Pozdnyakova Natalia Heorgiivna Sivko Roman Tarasenko Alla S Trikash Iryna Olegivna Shaturskyi Oleh Ya. popup.nrat_date 2024-01-08 Close