Registration Number
0224U000473,
(0119U002509)
, R & D reports
Title
Molecular mechanisms of regulation and multidirectional modulation of the transport of excitatory and inhibitory neurotransmitters in the presynapse in norm and neuropathology
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Молекулярні механізми регулювання та різноспрямоване модулювання транспорту збуджуючих та гальмівних нейромедіаторів у пресинапсі у нормі та за умов нейропатологій
Head
Borysova Tetiana O., Доктор біологічних наук
Registration Date
08-01-2024
Organization
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine
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The results are essential for solving current problem regarding the mechanisms that determine the transport vector of neurotransmitters through the plasma membrane of the presynapse; the role of the structural organization of the membrane in the regulation of nerve impulse transmission; the role of presynaptic receptors in the regulation of key stages of neurotransmission and determining the ways of modulation of the neurotransmitter reception system; analysis of the molecular mechanisms of action of existing and new membranotropic and neuroactive drugs and create a biochemical basis and open ways to overcome neurological disorders. In the framework of nanoneurotoxicology research direction, the functional state of the exocytosis system, the transporter-mediated accumulation/release of neurotransmitters in the nerve terminals of the rat brain, and the ion-conducting properties of the planar phospholipid bilayer under the influence of various types of nano- and micro-particles were studied. Gadolinium-containing nanohybrids AGuIX with a proven ability to treat brain metastases did not show a neurotoxic effect, in contrast to their components. The ability of nanodiamonds to facilitate the ion transport through the lipid bilayer by forming ion-conducting channels in bilayer phospholipid membranes was determined. A unique compound, a derivative of 4-thiozolidinone, capable to modulate in the opositely directional manner the processes of excitation and inhibition in the nerve terminals of the brain was identified. Using a cell-free system that reproduces the stage of the compound exocytosis - the fusion of homotypic membranes, it was shown that after oral administration of the antiepileptic drug levetiracetam, the calcium-dependent fusion of synaptic vesicles decreased. The cationic biocide polyhexamethyleneguanidine hydrochloride caused a dose-dependent depolarization of the plasma membrane of brain nerve terminals and platelets and formed K+-selective potential...
Product Description
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Borisov Arseniy A
Dudarenko Marina Volodymyrivna
Kanyuk Mykola Igorovych
Kasatkina Ludmila Olexandrivna
Krisanova Natalia Valeriivna
Nazarova Anastasiya Georgiyivna
Panas Ihor Dankovych
Pastukhov Artem Olegovych
Pyrshev Kyrylo O
Pozdnyakova Natalia Heorgiivna
Sivko Roman
Tarasenko Alla S
Trikash Iryna Olegivna
Shaturskyi Oleh Ya.
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2024-01-08
