Registration Number
0224U000522,
0121U107572
, R & D reports
Title
Develop highly specific criteria for individual prognosis, prevention and treatment of preterm birth
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Head
Vorobiova Iryna I., Доктор медичних наук
Znamenska Tetiana K., Доктор медичних наук
Skrypchenko Nataliia Ya., Доктор медичних наук
Registration Date
09-01-2024
Organization
State Institution "Institute of pediatrics, obstetrics and gynecology named after acad. O. M. Luk'yanova of National academy of medical sciences of Ukraine"
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As a result of the implementation of the NDR, highly specific criteria for the individual prognosis of premature birth and PRPO in premature pregnancy were established. On the basis of the determined hormonal, immune, bacteriological, psychological, histological, instrumental-diagnostic parameters, the pathogenetic mechanisms of the development of premature birth were specified. It has been established that inflammatory reactions in the placenta develop in the dynamics of the placenta's evolution, and as the gestation period increases, the signs of inflammatory reactions increase in quantitative characteristics and spread to all structures of the placenta. That is, it has been proven that the prolongation of pregnancy to increase the gestational age of the fetus, the term of gestation (in the absence of dangerous conditions in the mother and the fetus) is reasonably safe and contributes to increasing the survival of infants and reducing their disability. A set of measures (treatment, childbirth tactics) has been developed for each period of pregnancy. The study of the mechanisms of the implementation of infectious agents in the mother-placenta-fetus system established that the bacteriological-virological associations that lead to PRPO develop from the period of pre-gravid remodeling of the endometrium, their implementation is associated with the genetic prerequisites of the mother and fetus (in particular, factors of innate immunity TLR-9) and immune responses occurring on the mucous membranes, in particular the cervical canal (the lysozyme system and immunoglobulins of various classes). The technology of pre-gravid preparation for women with a history of pregnancy losses and treatment in the dynamics of pregnancy was developed, which made it possible to determine the efficiency coefficients of therapy: -11.4% of premature births with a minimum term of 34 weeks; -5.5% of frozen pregnancies in the first trimester; -6.8% of interruptions in the 2nd trimester; t
Product Description
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Bondarenko Yuriy M
Zhivetskaya-Denisova Alla A.
Zadorozhna Tamara D.
Lozova Liliya A.
Rudakova Nadiya V.
Strizhak Svitlana К.
Tkachenko Victoria B.
Tolkach Serhiy M.
Shamayeva Olena V.
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2024-01-09
