Registration Number
0224U000574,
(0119U002324)
, R & D reports
Title
Photobiomodulation action of low-level light radiation with optical specter range on blood system of rats with I type diabetes mellitus
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Фотобіомодуляційна дія низькоінтенсивного світлового випромінювання оптичного діапазону спектра на систему крові щурів за умов цукрового діабету 1-го типу
Head
Lyuta Mariana Ya., Кандидат біологічних наук
Sybirna Nataliya O., д.б.н.
Registration Date
09-01-2024
Organization
Ivan Franko National University of Lviv
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The influence of photobiomodulation therapy (PBMT) on some hematological indices under conditions of DM is investigated. The increase of erythrocytes number and decrease of reticulocytes number, the increase in resistance of erythrocyte membranes to the action of acid hemolytic under the conditions of DM and the action of PBMT. The decrease in the level of lipid peroxidation products in blood plasma, erythrocytes and leukocytes was revealed, but the content of ROS in the leukocytes of rats with DM did not change under the action of PBMT. An increase in the activity of catalase and SOD, the decrease in the content of OMP in leukocytes lysates and AOPPs and AGEs in the blood plasma of rats with DM under the action of PBMT was revealed. There was a decrease in the content of AOPPs and AGEs in leukocytes lysates during DM and an increase under the conditions of DM and the action of PBMT. Under the conditions of DM and the action of PBMT, NOS activity and nitrite level decreases, the activity of MPO changes in different directions: it decreases in blood plasma and increases in leukocyte lysates. The decrease in the concentration of glucose in blood and the content of glycosylated hemoglobin under the conditions of DM and PBMT action was revealed. Improved tolerance of animals to glucose loading has been established. The decrease in the absorption activity of the fluorescent glucose analogue by leukocytes under DM conditions and the increase under the action of PBMT was revealed. The decrease in the content of ATP in leukocytes under the conditions of DM and the increase under the action of PBMT were established. The influence of PBMT on the functional state of rat leukocytes under DM conditions and PBMT action was investigated. The hypoglycemic effect of PBMT, as well as its normalizing effect on prooxidant / antioxidant balance and functional state of leukocytes due to its ability to increase glucose uptake by cells and normalize their energy supply are explained.
Product Description
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Yefimenko Nataliia V.
Karmash Oleksandr I.
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2024-01-09
