Registration Number
0224U001908,
0121U107434
, R & D reports
Title
Study of the features of the influence of binary radiation technologies on human malignant cells in vitro
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Head
Lavrenchuk Halyna Yo., д.б.н.
Talko Victoriia V., Доктор медичних наук
Registration Date
02-02-2024
Organization
State institution "National Scientific Center of Radiation Medicine of the National Academy of Medical Sciences of Ukraine"
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Object of research: biological effects in human malignant cell cultures under the combined influence of binary radiation technologies. Objective: to investigate the structural and morphofunctional changes in the test system of human non-small cell lung cancer cells (line A-549) in a resting state, irradiated with X-rays in the presence of the gadolinium-containing photon-capturing agent "Dotavist" and light of the optical range (red light ) in combination with the photosensitizer "Photolon". Research methods: method of transplantable culture of malignant human cells, methods of irradiation with X-rays, red light, cytological, statistical. The peculiarities of morphofunctional changes in the culture of malignant human cells under the separate and combined influence of two binary radiation technologies were investigated. It has been established that the combination of the applied photon-capturing technology and photodynamic influence increases the efficiency of devitalization of human non-small cell lung cancer cells (line A-549) in a resting state. The obtained results essentially form the basis of the preclinical stage of evaluating the effectiveness of drugs used in binary technologies, in particular "Dotavist" in the case of the photon capture method and "Photolon" for photodynamic therapy.
Product Description
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Atamanyk Natalia P.
Dmytrieva Inna R.
Oleinikova Tetiana H.
Pochapinckui Oleksiu D.
Chernyshov Andrii V.
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2024-02-02
