Registration Number
0224U002919,
0121U110302
, R & D reports
Title
Transcriptional and functional adaptation of pancreatic and liver mitochondria to dietary factors
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Head
Manko Volodymyr V., Доктор біологічних наук
Registration Date
14-03-2024
Organization
Ivan Franko National University of Lviv
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It has been established that when stability of uncoupled respiration is higher,
cell viability of isolated pancreatic acini also increases. For the first time it was shown
that the cause of the decrease in the membrane potential of mitochondria as a result of the action
of yellow acid TLC-S in a concentration of 0.5 mmol/l is the disruption of the oxidation of alanine,
but not pyruvate. An automated software algorithm solution for
analysis of polarographic records with automatic correction of artifacts,
oscillatory and random noises and searching for optimal areas for calculation
may be used by other researchers. The results of this study can
be used to develop preventive measures aimed at
preventing the development of diseases of the pancreas. They can be
implemented in the educational process at Lviv National University
named after Ivan Franko, as well as in other educational institutions of higher education in Ukraine
during teaching courses "Physiology of human and animals", "Physiology of
digestion", "Fundamentals of bioenergetics", "Systemic physiology", "Fundamentals of healthy
nutrition" and "Fundamentals of nutrition science".
Product Description
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Bilonoha Olha O.
Anastasiia M. Zub
Mazur Halyna M.
Bohdan V. Manko
Manko Bohdan O.
Manko Volodymyr V.
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2024-03-14
