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Information × Registration Number 0224U002963, 0122U002452 , R & D reports Title To develop radionuclide and cytological determinants for evaluating the effectiveness of targeted therapy of iodine-negative metastases of differentiated thyroid cancer popup.stage_title Head Solodiannykova Oksana I., д.мед.н. Registration Date 19-03-2024 Organization National Cancer Institute popup.description2 The object of the study is 20 patients with iodine-negative metastases of DSCLC. The purpose of the work is to evaluate the immediate results of the treatment of iodine-negative metastases in SCI, based on the use of radionuclide diagnostic methods with non-iodine RFP, the possibilities of PET/CT with 18F-FDG and cytological determinants (thyroid peroxidase, cytokeratin-17, the presence of phenotypic heterogeneity of the epithelium) . Research methods and equipment – scintigraphy of the whole body with 99mTc-MIBI; whole body scintigraphy with 99mTc-DMCA; positron emission tomography with 18F-FDG; methods of statistical processing of results; two-detector gamma camera of the company "Mediso" (Hungary), single-photon emission computed tomography (SPECT) "E. CAM 180”. 20 patients with DSCLC were examined, 10 of them treated with the targeted drug sorafenib, underwent SVT with 99mTc-MIBI in order to evaluate the therapeutic effectiveness by scintigraphic imaging. A method of treatment with drugs, tyrosine kinase inhibitors, of iodine-negative metastases of DSCLC has been developed. A scintigraphic assessment of the effectiveness of treatment using PET with 18F-FDG was carried out in 10 patients with DDD and iodine-negative metastases. In 8 patients, in whom bone damage was detected, treatment was carried out with the help of radionuclide and remote radiation therapy. Control of treatment effectiveness was carried out using SVT with 99mTc-MDR. Received 3 acts of implementation of the results of the 2nd stages of the NDR: KNP "Kyiv City Clinical Oncology Center"; Regional Clinical Oncology Center of the Kirovohrad Regional Council; Institute of Endocrinology and Metabolism named after ac. Commissioner of AMNU. Product Description popup.authors Danylenko Victoriia V. Dzhuzha Dmytro O. Sukach Heorhii H. popup.nrat_date 2024-03-19 Close