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Registration Number

0224U002963, 0122U002452 , R & D reports

Title

To develop radionuclide and cytological determinants for evaluating the effectiveness of targeted therapy of iodine-negative metastases of differentiated thyroid cancer

Head

Solodiannykova Oksana I., д.мед.н.

Registration Date

19-03-2024

Organization

National Cancer Institute

Description

The object of the study is 20 patients with iodine-negative metastases of DSCLC. The purpose of the work is to evaluate the immediate results of the treatment of iodine-negative metastases in SCI, based on the use of radionuclide diagnostic methods with non-iodine RFP, the possibilities of PET/CT with 18F-FDG and cytological determinants (thyroid peroxidase, cytokeratin-17, the presence of phenotypic heterogeneity of the epithelium) . Research methods and equipment – scintigraphy of the whole body with 99mTc-MIBI; whole body scintigraphy with 99mTc-DMCA; positron emission tomography with 18F-FDG; methods of statistical processing of results; two-detector gamma camera of the company "Mediso" (Hungary), single-photon emission computed tomography (SPECT) "E. CAM 180”. 20 patients with DSCLC were examined, 10 of them treated with the targeted drug sorafenib, underwent SVT with 99mTc-MIBI in order to evaluate the therapeutic effectiveness by scintigraphic imaging. A method of treatment with drugs, tyrosine kinase inhibitors, of iodine-negative metastases of DSCLC has been developed. A scintigraphic assessment of the effectiveness of treatment using PET with 18F-FDG was carried out in 10 patients with DDD and iodine-negative metastases. In 8 patients, in whom bone damage was detected, treatment was carried out with the help of radionuclide and remote radiation therapy. Control of treatment effectiveness was carried out using SVT with 99mTc-MDR. Received 3 acts of implementation of the results of the 2nd stages of the NDR: KNP "Kyiv City Clinical Oncology Center"; Regional Clinical Oncology Center of the Kirovohrad Regional Council; Institute of Endocrinology and Metabolism named after ac. Commissioner of AMNU.

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popup.authors

Danylenko Victoriia V.
Dzhuzha Dmytro O.
Sukach Heorhii H.