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Registration Number

0224U003115, 0122U000775 , R & D reports

Title

Physico-chemical aspects of forming a composite nanostructured biodegradable material for the treatment of damaged peripheral nerves

Head

Sukhodub Leonid F., д.ф.-м.н.

Registration Date

09-04-2024

Organization

Sumy State University

Description

 Object of research: processes of structural and phase features of the multicomponent biodegradable materials formation for use in practical neurosurgery, their physical properties: anisotropy of the structure, intermolecular interactions, kinetics of the in vitro drug release into a model environment. The purpose of the work is to establish the physicochemical regularities of the formation of biodegradable composite nerve conductors, modified with components of various origins (carbon nanoparticles, biologically active substances, proteins, drugs) in the form of tubes or plates and to lay a fundamental basis for the technological basis of creating biomaterials with given functional characteristics. The obtained during the second year of the project implementation results show the prospects of the proposed approaches for obtaining biodegradable nerve conductors with improved properties (degree of swelling, biodegradation, mechanical stability). For example, the obtained experimental data on electrical conductivity prove that the material containing graphene oxide has an electrical conductivity of 0.71∙10-2 Sm/cm, which is close to the natural nerve conductivity of 2.35∙10-2 Sm/cm

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Kumeda Mariia O.
Rebrii Yuliia O.
Sukhodub Leonid F.
Sukhodub Liudmyla B.
Tsyndrenko Oleksandr O.
Shevel Oleksandr E.