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Registration Number

0224U031390, 0121U109658 , R & D reports

Title

Features of electrophysiolodical and contractile reactions of smooth muscles to general anesthetics in conditions of insufficient oxygenation and oxidative stress and their pharmacolodical correction

Head

Soloviev Anatolii І., д.мед.н.

Registration Date

22-04-2024

Organization

Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine

Description

 The influence of the anesthetic Propofol on the functional activity of vascular SMC and hemodynamic parameters of rats under conditions of hypoxia and oxidative stress (diabetes mellitus (DM) and chemical modeling of ROS hyperproduction) was investigated. It has been shown that Propofol is able to affect the functional activity of the SMC of vessels, causing an increase in the magnitude of potassium currents (through BKCa channels) and dose-dependent dilation responses of the aorta, the main PA, and the IPA, which are likely to increase under conditions of DM. The effect of hypoxia on the background of Propofol caused a decrease in the values of constrictor reactions of PA and IPA segments of rats compared to the control. Propofol did not cause changes in hemodynamic parameters of healthy rats under conditions of normoxia (in vivo). However, under conditions of both diabetes and hypoxia, its action reduced heart rate and mean blood pressure in carotid arteries of rats. With the combined effect of diabetes and hypoxia, Propofol additionally reduced the pressure in the right ventricle of the heart, contributed to the occurrence of periods of sharp drop in blood pressure and bradycardia in 37.5% of animals.

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Іvanova Іryna V.
Dobrelia Nataliia V.
Parshykov Oleksandr V.
Sydorenko Vadym H.