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Information × Registration Number 0224U031645, 0123U102102 , R & D reports Title Expanding the synthetically accessible chemical space of organic compounds for the purpose of the new drugs creation. popup.stage_title Head Riabukhin Serhii V., Доктор хімічних наук Registration Date 29-05-2024 Organization Taras Shevchenko National University of Kyiv popup.description2 The authors updated the state of affairs relating to the modern commercially available chemical space; gaps existing within the base were identified. A tool and procedure required for the identification of "white spots", especially within the class of heterocyclic compounds, are undergoing validation stage. A series of new methods for the synthesis of chemical scaffolds for filling the chemical space gaps and validation of methods for their identification have been developed. A multigram method for the synthesis of bis-noradamantane-1,2-dicarboxylic acid (1,2-stellanedicarboxylic acid) was developed. The acid turned out to be a valuable precursor for compounds containing a stellane fragment, and significantly expand the variety of available compounds with the adamantane framework. In addition to developed new scaled methods for the synthesis of the corresponding 1,2-stellanedicarboxylic and revealed prospects for its further modification, the mechanistic aspects of the reaction were fully elucidated. Such a deep understanding allows for a new assessment of the prospects of this class of compounds in any field of science and industry. With an intention to confirm the importance of methyl group introduction into small molecules, we synthesized 1-methyl-1,3-diaminocyclobutane derivatives, which, owing to their stereochemical potential, can exist in the form of several stereoisomers and thus significantly expand the chemical space of cyclobutane containing scaffolds. Another direction was to expand the variety of substituted tetrahydrofurans by synthesizing the corresponding functionalized derivatives comprising a b-bond fused carbocycle moiety. Thioallyl alcohol was introduced into the Prins reaction, leading to new types of thiopyrans. The development of a new class of thiopyrans, which have no analogues not only in Ukraine, but also in the world, deserves a special attention.  Product Description popup.authors Volochnyuk Dmytro M. Hrabchuk Halyna P. Hranat Dmytro S. Makhankova Valeriia H. Melnykov Kostiantyn P. Mytiuk Andrii P. Nosyk Pavlo S. Yevhen M. Ostapchuk Pashchenko Oleksandr Ye. popup.nrat_date 2024-05-29 Close