Registration Number
0224U031744,
0123U101953
, R & D reports
Title
Chemical burns of various genesis: mechanisms of local and systemic implementation, therapeutic correction using carbon nanocomposites.
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Head
Dziubenko Nataliia V., Кандидат біологічних наук
Registration Date
10-06-2024
Organization
Taras Shevchenko National University of Kyiv
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In the conducted studies, acidic and alkaline burns were modeled and characterized, with optimal concentrations of irritants and application times determined to create stable injuries. The acidic burn required a substantial healing time, with the burn area reduction by 41 %, 66 %, and 77 % on days 7, 14, and 21, respectively. Affected animals did not lose weight and showed no signs of systemic toxicity or mortality. A slight increase in creatinine in the blood serum on days 7 and 21 indicated the negative impact of the burn on the kidneys. Histopathological examination of skin samples revealed significant inflammation, swelling, and signs of necrosis after 7 days. Over the next 14 days, the intensity of inflammation decreased, whereas connective tissue accumulated, indicating healing and tissue remodeling processes. Hematological analysis indicated significant changes in blood composition. Characterizing the healing dynamics, an active organism response, shifts in the leukocyte formula, and an impact on the erythrocyte compartment were observed.
Alkaline skin burns required at least 2 weeks for healing, with indicators: a 37% reduction in the burn area on day 7 and a 71 % reduction on day 14. Biochemical analysis and histopathological examination confirmed less pronounced intensity of signs compared to acidic burns, and faster healing as well. Animals did not lose weight, experienced no systemic toxic reactions, and did not die. Hematological changes were similar to those observed in animals experienced acidic burns.
Product Description
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Ishchuk Arsen М.
Belinska Iryna V.
Bozhenko Bohdanа M.
Kuznietsova Halyna M.
Lysenko Ivan V.
Lysenko Tetiana L.
Milokhov Demyd S.
Rybalchenko Таras V.
Stupak Yuliia A.
Khylia Оlha V.
Yanchuk Petro І.
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2024-06-10
