Registration Number
0224U032685,
(0124U004068)
, R & D reports
Title
Development of an innovative wound healing agent based on nanomaterials with a wide spectrum of action for military and civilian medicine.
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Пошук та відбір перспективних біосумісних малотоксичних наноматеріалів та інших активних сполук для створення біологічно активної композиції (БАК) з антиоксидантною та репаративною дією.
Head
Yefimova Svitlana L., Доктор фізико-математичних наук
Registration Date
01-12-2024
Organization
Institute for Scintillation Materials of National Academy of Science of Ukraine
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Development of an experimental sample of a remedy for treatment of skin lesions of various nature (wounds, intertrigo, frostbite, burns, infections, irritations) with a wide range of biological effects (anti-inflammatory, antimicrobial, antifungal and reparative) based on a biologically active composition (BAC) that contains selected nanoparticles (NP) of REE orthovanadate, silver nanoparticles and other active ingredients; development of methods for BAC identification.
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Wounds of various types and origins are among the most common reasons for seeking medical care, including primary premedical assistance, both for military personnel and civilians located in high-risk areas of military conflict. Inadequate medical assistance significantly increases the risk of complications, secondary infections, and may lead to more complex recovery processes for injured military personnel or civilians. In some cases, it can result in severe infectious processes and disability. During the first phase of the project, nanoparticles (NPs) of rare-earth orthovanadates were selected and synthesized. These particles have the ability to influence the inflammatory process of a wound, which is critically important for wound healing, as prolonged inflammation can lead to undesirable processes that delay or sometimes prevent wound closure. Other components and organic substances were selected as the base for the gel and the «liquid bandage» for topical application. For the first time, it has been demonstrated that the synthesized NPs and their composition with other components are non-toxic when administered intragastrically and do not exhibit allergenic or sensitizing effects when applied topically. In vivo experiment on models of healthy laboratory animals and animals with induced diabetes showed that selected gadolinium orthovanadate nanoparticles accelerated wound closure in healthy mice and improved healing in diabetic mice, where wound healing is typically delayed. The use of redox-active NPs enhanced the reparative and anti-inflammatory activities of the treatment, increased the contractile effect on the wound, reduced the likelihood of wound infection, and improved the chances of healing without bacterial inflammation and scarring. Thus, in the future, the significant outcome will be a substantial reduction in the duration of skin injury treatment when used in challenging conditions.
Product Description
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Yefimova Svitlana L.
Bielkina Inna O.
Hryhorova Hanna V.
Karpenko Nina O.
Klochkov Volodymyr K.
Siedykh Olha O.
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2024-12-01
