Registration Number
0224U032784,
(0123U103551)
, R & D reports
Title
Development of the technology of biocompatible antibacterial coatings of orthopedic implants by the gas-detonation deposition method for the needs of military and civilian medicine
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Синтез фосфаткальцієвих шарів при прямій взаємодії прекурсорів в детонаційній хвилі в процесі ГДО та легування шарів сріблом.
Head
Bieliaiev Oleksandr Ye., Доктор фізико-математичних наук
Registration Date
05-12-2024
Organization
V. Lashkarev Institute of Semiconductor Physics of National Academy of Sciences of Ukraine
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The goal of the project is to develop an effective and economically attractive technology of gas-detonation deposition of biocompatible and antibacterial layers based on calcium phosphates on orthopedic implants for the needs of military and civilian medicine.
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Object of study – processes of gas-detonation spraying of calcium phosphate and hydroxyapatite powders on metal and polymer (PEEK) substrates.
Subject of study – physical mechanisms of the formation of calcium-phosphate and hydroxyapatite (HAP) coatings, their structural, morphological, and antibacterial properties.
Aim of the Project – the development of the effective and economically viable technology of gas-detonation spraying of biocompatible and antibacterial layers based on calcium phosphates on the orthopedic implants for the needs of military and civilian medicine.
Investigation methods – X-ray diffractometry, Raman spectroscopy, scanning electron microscopy, electron paramagnetic resonance (EPR), biological testing of antibacterial properties by disc-diffusion method (DDM).
The gas-detonation method (GDS) was used to form the biocompatible hydroxyapatite-based protective coatings on the polymer (polyetheretherketone, PEEK, fluoroplastic) and metal (copper, titanium) substrates.
For the first series of experiments, the high-purity commercial (CHEMLABORREAKTIV LLC) hydroxyapatite powder with a fraction of 50 µm was used. For the second series of experiments, synthesized by the method of solid-state reactions, hydroxyapatite powder was used as well as for the third one – the simple precursor salts Ca(OH)2 and (NH4)2HPO4. To provide the antibacterial properties of the coatings, salt AgNO3 was added to the working powder. The obtained HAP/PEEK and HAP/metal coatings have a thickness equal to 20 µm and a porous structure. These coatings predominantly consist of hydroxyapatite with a small part of tricalcium phosphate (TCP) and defective HAP/oxyapatite phases. EPR study demonstrates the absence of paramagnetic defects in the formed HAP coatings and their increased radiation hardness compared with the initial powders. It was ascertained that in the case of PEEK polymer, the spraying time, as well as spraying distance, have no substantial influence on the HAP/TC
Product Description
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Boltovets Praskovia M.
Valakh Mykhailo Ya.
Vorona Ihor P.
Kaliushnyi Vladyslav V.
Karnauhov Anatolii V.
Lozinskyi Volodymyr B.
Nasieka Yurii M.
Temchenko Volodymyr P.
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2024-12-05
