Registration Number
0224U032803,
(0112U004271)
, R & D reports
Title
Monitoring of ecological and hygienic environment and its impact on public health
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Моніторинг еколого-гігієнічного стану довкілля та його вплив на здоров'я населення
Head
Погорєлов Максим Володимирович,
Registration Date
05-12-2024
Organization
Sumy State University
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Research object: thyroid gland.
The purpose of the work is to determine the effect of body dehydration, as an environmental factor, on the structure and function of the thyroid gland.
The subject of research is morphological and functional changes of the thyroid gland.
Research methods: histological, immunohistochemical, chemical-analytical, statistical.
It was found that the most drastic changes occur under conditions of extracellular dehydration at all stages of the study. Disruption of the compensatory and adaptive capabilities of the tissue and the organ as a whole was observed even under conditions of a mild degree. Already on the 30th day, we note significant changes in organometric, morphometric and histological indicators.
The mass of the thyroid gland became significantly smaller compared to the intact group of animals due to the reduction of follicles and the replacement of the epithelial part of the parenchyma with connective tissue. The weight and volume indicators acquired the greatest changes: the AM thyroid gland became smaller by 20.25% (р˂0.001), and the volume of the thyroid gland decreased by 23.21% (р˂0.001). With regard to morphometry, the most significant changes are observed in the indicators of the areas of follicles and colloid, which decreased by 103.91% (р˂0.001) and 197.33% (р˂0.001), respectively, as well as the INC indicator, which increased by 92 .08% (р˂0.001). A chemical-analytical study of the thyroid gland revealed a decrease in the content of Na, K, Ca, Cu, Zn and an increase in Mg, Mn, Fe
Product Description
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Dryhval Bohdan О.
Pohorielov Maksym V.
Khomenko Yuliia O.
Yusupova Aziza F.
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2024-12-05
