Registration Number
0224U032808,
(0121U110829)
, R & D reports
Title
To investigate immunoresistance and mechanisms of vascular disorders in healthy and children with rheumatic diseases after COVID-19
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Дослідити імунорезистентність та механізми судинних порушень у здорових та у дітей з ревматичними захворюваннями, які перехворіли на COVID-19
Head
Antypkin Yurii Н., Доктор медичних наук
Registration Date
05-12-2024
Organization
State institution «Ukrainian center of maternity and childhood of the National academy of medical sciences of Ukraine»
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Тo preserve and improve the health status of children who have had COVID-19, based on the determination of markers of immunological, metabolic and vascular disorders in healthy and children with rheumatic diseases by improving the longitudinal observation algorithm.
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Key words: CHILDREN, COVID-19, CARDIOVASCULAR DISEASES, ENDOTHELIAL FUNCTION, RHEUMATIC DISEASES, MICROCIRCULATORY DYSFUNCTION
Object of study: children of preschool and school age. 101 children without chronic diseases who had SARS-CoV-2 infection, 44 healthy children; 46 children with juvenile scleroderma (JSD), 55 children with juvenile idiopathic arthritis (JIA); 52 children without JIA who had COVID-19 and 40 children who did not have COVID-19.
Goal of study: to preserve and improve the health status of children after COVID-19 by identifying markers of immunological, metabolic and vascular disorders in healthy children and children with rheumatic diseases by improving the algorithm of longitudinal observation.
Methods of research: clinical, immunological, biochemical, instrumental (methods of cardiovascular system research, laser Doppler fluometry, digital capillaroscopy), mathematical, statistical.
Measuring equipment: immunoenzyme photoelectric analyzer Reeder ER 500 No. ER2J018E, 03.2013, computerized laser blood microcirculation analyzer LAKK-02, Levenhuk DTX 500 Mobi microscope, Mindrey DS 80 ultrasound, electrocardiograph Yukard 100, FACScan flow cytometer No. 81456.
The obtained data shows and prove the negative impact of SARS-CoV-2 infection on the development of endothelial dysfunction, worsening of the cardiovascular system response to exercise, a significant decrease in blood flow velocities in the arterial and venous capillary compartments, as well as on the course of rheumatic diseases (JIA, JIA) in children.
The scientific novelty of research is to determine the correlation between the state of endothelial dysfunction and the development of cardiovascular complications in healthy children and children with JIA who have had coronavirus infection and to determine the prognostic value of hemodynamic and MC disorders in children with JIA who have had COVID-19 for their timely correction.
The work is security-conscious.
Product Description
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Ihnatova Tetiana B.
Donskyi Borys V.
Diachenko Nina M.
Kvashnina Liudmyla V.
Kravchenko Olena M.
Lutsenko Iryna R.
Liudvik Tetiana A.
Matviienko Iryna M.
Mukvich Olena M.
Omelchenko Liudmyla I.
Senchuk Liudmyla M.
Stryzhak Svitlana K.
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2024-12-05
