Registration Number
0224U032841,
(0123U103756)
, R & D reports
Title
Development of components of antimicrobial drugs to increase the effectiveness of their action and prevent resistance of microorganisms
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Вивчення антибактеріальних властивостей похідних дііндолілметану. Розробка аналітичних методик контролю якості синтезованих сполук. Експериментальна оцінка стабільності супрамолекулярних комплексів похідних дііндолілметану.
Head
Lipson Viktoriia V., д.х.н.
Registration Date
09-12-2024
Organization
State Scientific Institution Scientific and Technological Complex" Institute of Single Crystals "of the National Academy of Sciences of Ukraine
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The synthesis, research and standardization of diindolylmethane and its analogues and their supramolecular complexes for further use in the development of the innovative antimicrobial drugs and/or disinfectants.
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The report contains an analysis of literature data on the mechanisms of development of resistance of microorganisms to antibacterial drugs and the possibility of its prevention with the help of various indole derivatives, a project of a scientific article has been prepared. A number of 3,3'-DIM derivatives were synthesized. Molecular docking showed that the DIM ligand binds primarily to β-CD in its open conformation. Experimental samples of DIM complexes with α-CD and β-CD were obtained. The solubility of DIM in nine solvents, including those used in pharmacy, was determined. An experimental evaluation of the antibacterial activity of such solutions was carried out on museum cultures of microorganisms. It was established that the 0.5% solution of DIM in N-methylpyrrolidone exhibits the greatest antimicrobial activity among all the tested samples in relation to reference strains of bacteria and is characterized by a pronounced antimicrobial antifungal effect against Candida albicans, as well as the ability to diffuse into agar. The effectiveness and spectrum of its antimicrobial effect does not change during the month. The results were presented at two Ukrainian conferences with international participation.
Product Description
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Bezuhla Olena P.
Vakula Volodymyr M.
Zinchenko Ihor O.
Viktoriia V. Lipson
Liapunov Mykola O.
Liapunova Anna M.
Mishyna Maryna M.
Malanchuk Svitlana H.
Miasnikova Dariia Yu.
Pinchukova Nataliia O.
Sirous Volodymyr O.
Tsyhankov Oleksandr V.
Cherniakova Marharyta Yu.
Shyrobokova Mariia H.
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2024-12-09
