Registration Number
0224U033013,
(0124U003794)
, R & D reports
Title
Automated integrated sensory system based on the phenomenon of surface plasmon resonance for express control of signs of particularly dangerous oncopathologies
popup.stage_title
Створення автоматизованої інтегрованої сенсорної системи (АІСС) на основі явища поверхневого плазмонного резонансу (ППР) для контролю ознак особливо небезпечних онкопатологій
Head
Khomenkova Larysa Yu., Доктор фізико-математичних наук
Registration Date
15-12-2024
Organization
V. Lashkaryov Institute of Semiconductor Physics of National Academy
popup.description1
Creating an automated integrated sensory system (AISS) based on the phenomenon of surface plasmom resonance (SPR) with high sensitivity, accuracy and reproduction of the result of measurement with the involvement of new hardware on the basis of "Plasmon" devices for express control of signs (markers or processes) of particularly dangerous cancer leading to high mortality or disability.
popup.description2
During the first stage of the project, an automated integrated sensor system (AISS) based on the phenomenon of surface plasmon resonance (SPR) was developed. The main component of the system is the two-channel SPR device "Plasmon-6," designed at the V.E. Lashkaryov Institute of Semiconductor Physics of the NAS of Ukraine. The AISS is integrated with program-controlled pumps, a channel switch, a cuvette air dryer, and a thermobox. The operational parameters, including the flow rate (22±10 μL/min) and temperature (+22±1 °C), were optimized, which allowed for increased measurement accuracy. The AISS operates in automatic regime allowed the increase of system's sensitivity (by 1.4 times) and the reduction of the cost reagent consumption (by 7.3 times). The system is autonomous, mobile, and can be employed not only in laboratories but also in field conditions.
The developed system is promising for biomedical research and the diagnosis of oncological diseases. The methodology, based on the functionalization of the sensor surface, minimizes nonspecific interactions. This system is unique and has no analogs. This opens up opportunities for early tumor recurrence diagnostics and improved glioma treatment. AISS has been applied to study blood cell aggregation associated with brain glioma relapse using biological material from volunteer patients and laboratory animals, while adhering to all relevant regulations.
The results obtained during the first stage of the project have been published in scientific journals (2 in Q3 journals, 1 in a B-category journal), as well as in the proceedings of two conferences. Two presentations were made at international conferences related to the project. A patent application has been applied.
Product Description
popup.authors
Hrydina Nina Ya.
Dorozhynskyi Hlib V.
Zalietok Sofiia P.
Samoilov Anton V.
Khrystosenko Roman V.
popup.nrat_date
2024-12-15
