Registration Number
0224U033164,
(0123U100008)
, R & D reports
Title
To investigate the course of arterial hypertension and target organ damage in patients with comorbid pathology after COVID-19 and under the influence of military conflict іn Ukraine
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Дослідити перебіг артеріальної гіпертензії та ураження органів- мішеней у пацієнтів з коморбідною патологією на тлі перенесеного COVID-19 та під впливом військового конфлікту в Україні
Head
Kovalenko Volodymyr M., д.мед.н.
Registration Date
19-12-2024
Organization
State Institution "National Scientific Center "Institute of Cardiology, clinical and regenerative medicine named after academician M.D. Strazhesko" of the National Academy of Medical Sciences of Ukraine
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To study the influence of COVID-19 and factors of military conflict on clinical characteristics, structural and function target organ condition and immune-inflammatory status of arterial hypertension patients with comorbidities (diabetes mellitus, chronic kidney disease, ischemic heart disease).
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The object of the study is arterial hypertension (AH), morpho-functional state of the left ventricle (LV), kidney function, pro-inflammatory and metabolic factors, psycho-emotional state.
Purpose of the work – To investigate the nature of target organ damage, psycho-emotional state, endothelial function and activity of systemic inflammation in patients with AH after suffering COVID-19 and under the influence of the military conflict in Ukraine.
Research methods – general clinical, Doppler echocardiography, daily blood pressure monitoring, biochemical, determination of platelet functional activity, questionnaires (state of anxiety, depression, cognitive function, adherence to treatment).
It was found that in the cohort of patients participating in hostilities, signs of depression are more often observed than anxiety, insufficient decrease in blood pressure during sleep, increased blood pressure variability, concentric changes in the LV of the heart, disorders of the blood lipid spectrum, especially hypertriglyceridemia, disorders of endothelial function. These disorders are more common among patients with long-term hypertension and with a history of acubarotrauma. It has been established that vaccination against COVID-19 in patients with a history of coronavirus infection contributes to the prolongation of COVID-19-induced systemic endothelial dysfunction. The use of acetylsalicylic acid contributes to a statistically significant reduction in markers of systemic inflammation, the level of blood platelet activation, a decrease in their ability to aggregate and restore endothelial function, and the ability of the bone marrow to produce endothelial cell precursors.
Product Description
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Bezrodna Larysa V.
Bezrodnyi Volodymyr B.
Bozhenko Halyna M.
Vlasova Olena M.
Kupchynska Olena H.
Mishchenko Larysa A.
Matova Olena O.
Moroz Halyna Z.
Ponomariova Halyna V.
Radchenko Volodymyr V.
Talaieva Tetiana V.
Tkachuk Iryna M.
Tretiak Iryna V.
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2024-12-19
