Registration Number
0224U033229,
(0121U111583)
, R & D reports
Title
Determination of genetic characteristics of individuals with severe COVID-19 for early prediction of treatment strategy
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Визначення генетичної характеристики пацієнтів з тяжким перебігом COVID-19 для раннього прогнозування стратегії лікування
Head
Horovenko Nataliia Н., д.мед.н.
Registration Date
22-12-2024
Organization
State Institution "National Scientific Center "Institute of Cardiology, clinical and regenerative medicine named after academician M.D. Strazhesko" of the National Academy of Medical Sciences of Ukraine
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To investigate the effect of gene variants on the course of severe forms of COVID-19 in subjects treated in intensive care units
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For the first time in Ukraine, the genotype frequencies of the genetic variants SFTPB, NR3C1, NOS3, IL1Β, and IFNG were studied in patients with severe COVID-19. For the first time worldwide, NAT2 gene variants were investigated in the context of severe COVID-19-associated pneumonia. It was found that the genotypes of NOS3, IL1Β, IFNG, and NAT2 significantly differ from population frequencies and are associated with an increased risk of severe pneumonia. Variants of SFTPB and NAT2 were linked to the development of acute respiratory distress syndrome and the need for mechanical ventilation. Furthermore, the influence of SFTPB, NR3C1, and IL1Β variants on the duration of therapeutic interventions in intensive care unit patients was established. The study results highlight the significant impact of genetic variants on the course of COVID-19, provide substantial insight into the pathogenesis of the disease and its individual risks, and may serve as a basis for personalized treatment tailored to the genetic characteristics of patients.
Product Description
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Yevseienkova Olena H.
Buriak Oleksandr A.
Vlasova Olena M.
Levkovych Nataliia Ye.
Mytsyk Nataliia Yo
Mostoviak Mariana P.
Olkhovych Volodymyr P.
Olkhovych Natalia V.
Podolska Svitlana V.
Rossokha Zoia I.
Stroi Dmytro О.
Tavokina Lyubov V.
Trofimova Natalia S.
Fishchuk Liliia Ye.
Sheiko Larysa P.
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2024-12-22
